Application of Plackett-Burman Factorial Design in The Development of Curcumin Loaded Eudragit E 100 Nanoparticles

Application of Plackett-Burman Factorial Design in The Development of Curcumin Loaded Eudragit E 100 Nanoparticles

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The present study was aimed to fabricate Curcumin loaded Eudragit E 100 polymeric nanoparticles and to study the effect of various manufacturing parameters on the average particle size, span, uniformity and surface area of the prepared polymeric nanoparticles by utilizing Plackett-Burman experimental designs.Curcumin loaded Eudragit E 100 nanoparticles were dorisvale station for sale prepared by nanoprecipitation method and characterized using particle size analyser.Plackett-Burman design was implemented to study the influence of eight independent variables on three dependent variables.

Twelve experimental trials involving 8 independent variables at higher and lower levels were generated by Design-Expert.Out of 12 trials, 4th and 9th trails were within the acceptable limits.Least average particle size can be obtained by increasing the concentration of poloxamer 188, increasing the volume of aqueous phase, increasing the sonication duration and decreasing the ethanol concentration.

Similarly, span less than 1 can be obtained by increasing the concentration of poloxamer 188, increasing the sonication duration catherine lansfield ombre rainbow clouds eyelet curtains and decreasing the ethanol concentration.However, uniformity can be increased decreasing the ethanol concentration.Higher surface area can be obtained by increasing the concentration of Eudragit E 100, poloxamer 188 and increasing the volume of the aqueous phase.